The teamStaffLada Ivanova    October 23, 2018
Lada Ivanova, Dr. philos.

Section for Chemistry
Norwegian Veterinary Institute
Ullevålsveien 68
0454 Oslo/Norway

Tel.: +47/2321 6221
Fax: +47/2321 6201

Research interest
Isolation, purification and identification of secondary metabolites from fungi and plants. Mechanistic studies of natural toxins in bioassays.

Master’s degree in analytical chemistry from the University of Kiev, Ukraine. Master’s degree in food safety from the Norwegian School of Veterinary Science Oslo/Norway. Professional experience from numerous projects and studies in the field of mycotoxin analysis, incorporating both method development and extensive work with quality assurance and statistics. Member of the working group for biotoxins (WG5) under The Technical Committee 275, “Food analysis-Horizontal methods”, within the CEN system (2005-2010). Scientist at the Norwegian Veterinary Institute since 2006.
Original publications
    Ivanova, L.; Fæste, C.K.; Delezie, E.; Van Pamel, E.; Daeseleire, E.; Callebaut, A.; Uhlig, S. Presence of enniatin B and its hepatic metabolites in plasma and liver samples from broilers and eggs from laying hens. World Mycotoxin Journal, in press.
    Uhlig, S.; Ivanova, L.; Fæste, C.K. Enzyme-assisted synthesis and structural characterization of the 3‑, 8‑, and 15-glucuronides of deoxynivalenol. Journal of Agricultural and Food Chemistry 2013, 61, 2006-2012.
    Gammelsrud, A.; Solhaug, A.; Dendele, B.; Sandberg, W. J.;  Ivanova, L.; Kobach Bølling, A.; Lagadic-Gossmann, D.; Refsnes, M.; Becher, R.; Eriksen, G. S.; Holme, J. A. Enniatin B-induced cell death and inflammatory responses in RAW 264.7 murine macrophages. Toxicol. Appl. Pharmacol., accepted for publication. 
    Fæste, C.K.; Ivanova, L.; Uhlig, S. In vitro metabolism of the mycotoxin enniatin B in different species and CYP P450 reaction phenotyping. Drug Metabolism and Disposition 2011, 39, 1768-1776.
     Ivanova, L.; Fæste, C. K.; Uhlig, S. In vitro metabolism of the depsipeptide enniatin B. Analytical and Bioanalytical Chemistry 2011, 400, 2889-2901.
     Ivanova, L.; Uhlig, S.; Eriksen, G. S.; Johannessen, L. E. Enniatin B1 is a substrate of intestinal P-glycoprotein, multidrug resistance-associated protein 2 and breast cancer resistance protein. World Mycotoxin Journal 2010, 3 (3), 271-281.
     Ivanova, L.; Petersen, D.; Uhlig, S. Phomenins and fatty acids from Alternaria infectoria. Toxicon  2010, 55 (6), 1107-1114.
     Uhlig, S.; Ivanova, L.; Petersen, D.; Kristensen, R. Structural studies on minor enniatins from Fusarium sp VI 03441: Novel N-methyl-threonine containing enniatins. Toxicon 2009, 53 (7-8), 734-742.
     Ivanova, L.; Uhlig, S. A bioassay for the simultaneous measurement of metabolic activity, membrane integrity, and lysosomal activity in cell cultures. Analytical Biochemistry 2008, 379 (1), 16-19.
     Uhlig, S.; Ivanova, L.; Bernhoft, A.; Eriksen, G. S. 2-Amino-14,16-dimethyloctadecan-3-ol: in vitro bioactivity and bio-production by the fungus Fusarium avenaceum. World Mycotoxin Journal 2008, 1 (1), 49-58.
     Uhlig, S.; Vikoren, T.; Ivanova, L.; Handeland, K. Ergot alkaloids in Norwegian wild grasses: a mass spectrometric approach. Rapid Commun. Mass Spectrom. 2007, 21 (10), 1651-1660.
     Ivanova, L.; Skjerve, E.; Eriksen, G. S.; Uhlig, S. Cytotoxicity of enniatins A, A1, B, B1, B2 and B3 from Fusarium avenaceum. Toxicon 2006, 47 (8), 868-876.
     Uhlig, S.; Ivanova, L. Determination of beauvericin and four other enniatins in grain by liquid chromatography-mass spectrometry. Journal of Chromatography A 2004,  1050 (2), 173-178.

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