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The teamStaffIngunn Samdal    January 23, 2018
Ingunn Samdal, Dr. scient.
 



Section for Chemistry and Toxicology
Norwegian Veterinary Institute
Ullevålsveien 68
0454 Oslo/Norway

Tel.: +47/2321 6226
Fax: +47/2321 6201
E-mail: ingunn.samdal@vetinst.no
 
 
Research interest
Secondary metabolites of marine and freshwater algae – their isolation, purification and detection. Special interest in development of antibodies to recognise the metabolites and using the antibodies to developing immunological methods for detecting metabolites in food such as shellfish for the marine algal metabolites and in water for the freshwater algal metabolites. Especially interested in cyanotoxins/microcystins, okadaic acid and azaspiracids.
 
Background
Studies in biochemistry, chemistry and biology at the University of Oslo/Norway. Professional experience from The Biotechnology Centre of Oslo/Norway 1996-1998 and the Norwegian Veterinary Institute in Oslo 1998-2000. Doctoral degree from the Norwegian School of Veterinary Science Oslo/Norway in April 2005. Scientist at the Norwegian Veterinary Institute since then.
 
Ongoing projects
 
  • Target: Targeted strategies for safeguarding the noble crayfish against alien and emerging threats (NFR/243907) (2015-2018)
  • ECsafeSEAFOOD: Priority environmetal contaminants in seafood: safety assessment, impact and public perception (Grant no: 311820) (2013-2016)
 
 
Recent projects
 
  • FRIMUF: Development and validation of diagnostic tools for cyanotoxins in Southern Africa (NRC project nr. 196085) (2010-2014)
  • BIOTOX: Sixth framework EU program “Specific Targeted Research Project” entitled “Cost-effective tools for risk management and traceability systems for lipophilic marine biotoxins in seafood" (2005-2008)
  • Havbruk: "Marine algal toxins, ecology, analysis and toxicology" - NFR 139593/140 (2000-2004)
 
 
Original publications
 
       Samdal, I.A.; Løvberg, K.E.; Briggs, L.R.; Kilcoyne, J.; Xu, J.; Forsyth, C.J.; Miles, C.O.; Development of an ELISA for the detection of azaspiracids. Journal of Agricultural and Food Chemistry 2015, 63, 7855−7861.
       Samdal, I.A.; Ballot, A.; Løvberg, K.E.; Miles, C.O.
Multihapten approach leading to a sensitive ELISA with broad cross-reactivity to microcystins and nodularin. Environmental Science & Technology 2014, 48, 8035-8043.
     
Aasen, J. A. B.; Espenes, A.; Miles, C. O.; Samdal, I. A.; Hess, P.; Aune, T.  Combined oral toxicity of azaspiracid-1 and yessotoxin in female NMRI mice Toxicon 2011, 57, 909-917.
     Rundberget, T.; Gustad, E.; Samdal, I. A.; Sandvik, M.; Miles, C. O. A convenient and cost-effective method for monitoring marine algal toxins with passive samplers. Toxicon 2009, 53 (5), 543-550.
     Larsen, K.; Petersen, D.; Wilkins, A. L.; Samdal, I. A.; Sandvik, M.; Rundberget, T.; Goldstone, D.; Arcus, V.; Hovgaard, P.; Rise, F.; Rehmann, N.; Hess, P.; Miles, C. O. Clarification of the C-35 stereochemistries of dinophysistoxin-1 and dinophysistoxin-2 and its consequences for binding to protein phosphatase (vol 20, pg 868, 2007). Chemical Research in Toxicology 2007, 20 (12), 2020.
     Larsen, K.; Petersen, D.; Wilkins, A. L.; Samdal, I. A.; Sandvik, M.; Rundberget, T.; Goldstone, D.; Arcus, V.; Hovgaard, P.; Rise, F.; Rehmann, N.; Hess, P.; Miles, C. O. Clarification of the C-35 stereochemistries of dinophysistoxin-1 and dinophysistoxin-2 and its consequences for binding to protein phosphatase. Chemical Research in Toxicology  2007, 20 (6), 868-875.
    Forsyth, C. J.; Xu, J. Y.; Nguyen, S. T.; Samdal, I. A.; Briggs, L. R.; Rundberget, T.; Sandvik, M.; Miles, C. O. Antibodies with broad specificity to azaspiracids by use of synthetic haptens. Journal of the American Chemical Society 2006, 128 (47), 15114-15116.
   Samdal, I. A.; Aasen, J. A. B.; Briggs, L. R.; Dahl, E.; Miles, C. O. Comparison of ELISA and LC-MS analyses for yessotoxins in blue mussels (Mytilus edulis). Toxicon 2005, 46 (1), 7-15.
   Miles, C. O.; Samdal, I. A.; Aasen, J. A. B.; Jensen, D. J.; Quilliam, M. A.; Petersen, D.; Briggs, L. M.; Wilkins, A. L.; Rise, F.; Cooney, J. M.; MacKenzie, A. L. Evidence for numerous analogs of yessotoxin in Protoceratium reticulatum. Harmful Algae 2005, 4 (6), 1075-1091.
   Finch, S. C.; Wilkins, A. L.; Hawkes, A. D.; Jensen, D. J.; MacKenzie, A. L.; Beuzenberg, V.; Quilliam, M. A.; Olseng, C. D.; Samdal, I. A.; Aasen, J. A. B.; Selwood, A. I.; Cooney, J. M.; Sandvik, M.; Miles, C. O. Isolation and identification of (44-R,S)-44,55-dihydroxyyessotoxin from Protoceratium reticulatum, and its occurrence in extracts of shellfish from New Zealand, Norway and Canada. Toxicon  2005, 46 (2), 160-170.
     Aasen, J. A. B.; Samdal, I. A.; Miles, C. O.; Dahl, E.; Briggs, L. R.; Aune, T. Yessotoxin in Norwegian blue mussels (Mytilus edulis); uptake from Protoceratium reticulatum, metabolism and depuration. Toxicon 2005, 45 (3), 265-272.
    Samdal, I. A.; Olseng, C. D.; Sandvik, M.; Miles, C. O.; Briggs, L. R.; Torgersen, T.; Jensen, D. J.; Cooney, J. M. Profile of yessotoxin analogues in a Norwegian strain of Protoceratium reticulatum. In: Proceedings from the 5th International Conference on Molluscan Shellfish Safety, 14th-18th June 2004, Galway, Ireland , 2004.
    Samdal, I. A.; Naustvoll, L. J.; Olseng, C. D.; Briggs, L. R.; Miles, C. O. Use of ELISA to identify Protoceratium reticulatum as a source of yessotoxin in Norway. Toxicon 2004, 44 (1), 75-82.
    Miles, C. O.; Wilkins, A. L.; Samdal, I. A.; Briggs, L. R.; Aasen, J. A. B.; Cooney, J. M.; Jensen, D. J.; Hawkes, A. D.; Holland, P. T.; Petersen, D.; Quilliam, M. A.; Selwood, A. I.; MacKenzie, A. L.; Beuzenberg, V.; Munday, R. Protocertium reticulatum produces numerous yessotoxin analogues. In: Book of abstracts. 5th International Conference on Molluscan Shellfish safety, 14th-18th June 2004, Galway, Irland 2004, 44.
    Miles, C. O.; Wilkins, A. L.; Hawkes, A. D.; Selwood, A. I.; Jensen, D. J.; Aasen, J. A. B.; Munday, R.; Samdal, I. A.; Briggs, L. R.; Beuzenberg, V.; MacKenzie, A. L. Isolation of a 1,3-enone isomer of heptanor-41-oxoyessotoxin from Protoceratium reticulatum cultures. Toxicon 2004, 44 (3), 325-336.
    Miles, C. O.; Wilkins, A. L.; Samdal, I. A.; Sandvik, M.; Petersen, D.; Quilliam, M. A.; Naustvoll, L. J.; Rundberget, T.; Torgersen, T.; Hovgaard, P.; Jensen, D. J.; Cooney, J. M. A novel pectenotoxin, PTX-12, in Dinophysis spp. and shellfish from Norway.  Chemical Research in Toxicology 2004, 17 (11), 1423-1433.
    Miles, C. O.; Samdal, I. A.; Aasen, J. A. B.; Jensen, D. J.; Quilliam, M. A.; Petersen, D.; Briggs, L. R.; Wilkins, A. L.; Rise, F.; Cooney, J. M.; MacKenzie, A. L. Presence of numerous analogs of yessotoxin in Protoceratium reticulatum. Chemical Research in Toxicology 2004, (submitted).
    Samdal, I. A.; Sletten, K.; Olsen, K. E.; Westermark, P. AL 366 - a glycosylated protein of kappa 1b origin in a patient with systemic amyloidosis of predominantly non-parenchymatous distribution. Amyloid-Journal of Protein Folding Disorders 2001, 8 (2), 111-114.
     Bratberg, B.; Ulvund, M. J.; Benestad, S. L.; Thu, B.; Ersdal, C.; Samdal, I. A.  Patologi og diagnostikk av scrapie. Norsk Veterinærtidsskrift 2000, 112, 359-367.
     Samdal, I. A.  Karakterisering av en amyloid immunoglobin lett kjede fra en pasient med myelomatose assosiert med AL amyloidose. Thesis for the degree of Cand.Scientiarum in biochemistry at the Department of Biochemistry/Biotechnology Centre of Oslo, University of Oslo, Norway, 1998.
     Samdal, I. A.; Sletten, K.; Olsen, K. E.; Westermark, P.  Characterisation of an atypical amyloid fibril protein (AL 366) from a patient with multiple myeloma. In: "Amyloid and Amyloidosis 1998" - referral from The VIII International Amyloid Symposium, 7.-11.August 1998, Mayo Clinic, Rochester, Minnesota, USA,1998.
 
 
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