The teamStaffAnita Solhaug    January 23, 2018
Anita Solhaug, Dr. scient.

Section for Chemistry and Toxicology
Norwegian Veterinary Institute
Ullevålsveien 68
0454 Oslo/Norway

Tel.: +47/2321 6214
Fax: +47/2321 6201
E-mail: anita.solhaug@vetinst.no
Research interest

Toxicological characterisation of selected secondary fungal metabolites in Norwegian grain. My special interests are investigation of their mechanism of action, DNA damage, cell signalling and inflammation pathways. I use methods such as flow cytometry, western blot, ELISA and more. I love science!


Studies in biology, chemistry and biochemistry, at Sogn and Fjordane University College, Sogndal (1994 – 1995) and at the Norwegian University of Science and Technology (NTNU), Trondheim, Norway (1995 – 2000). Dr. scient. in Toxicology from the Norwegian Institute of Public Health, Oslo, Norway (2000 – 2005). Post doc in cell biology at Rikshospitalet University Hospital, Oslo, Norway (2005 – 2008). Guest researcher at Nordic Institute of Dental Materials, Oslo, Norway (2008). Post doc at the Norwegian Veterinary Institute, Oslo, Norway (2008 - ).

Original publications
    Stanic, A.; Uhlig, S.; Solhaug, A.; Rise, F.; Wilkins, A.; Miles, C.O. Nucleophilic addition of thiols to deoxynivalenol, J. Agric. Food Chem. 2015, 63, 7556-7566.   
    Solhaug, A.; Wisbech,C.; Christoffersen, T.E.; Hult, L.O.; Lea, T.; Eriksen, G.S.; Holme, J. The mycotoxin alternariol induces DNA damage and modify macrophage phenotype and inflammatory responses. Toxicol. Lett. 2015, 239, 9-21.   
    Holme,JA.; Nyvold,HE.; Tat,V.; Arlt,VM.; Bhargava,A.; Gutzkow,KB.; Solhaug,A.; Låg,M.; Becher,R.; Schwarze,PE.; Ask,K.; Ekeren,L.; Øvrevik.J. Mechanisms linked to differences in the mutagenic potensial of 1,3-dinitropyrene and 1,8-dinitropyrene. Toxicol. Rep. 2014, 1, 495-473.
    Solhaug, A.; Torgersen, M.L.; Holme, J.A.; Lagadic-Gossmann, D.; Eriksen, G.S. Autophagy and senescence, stress responses induced by the DNA-damaging mycotoxin alternariol. Toxicology 2014, 326, 119-129.
    Solhaug, A.; Holme, J.A.; Haglund, K.; Dendele, B.; Sergent, O., et al. Alternariol induces abnormal nuclear morphology and cell cycle arrest in murine RAW 264.7 macrophages. Toxicol. Lett. 2013, 219, 8-17.
    Gammelsrud, A.; Solhaug, A.; Dendele, B.; Sandberg, W. J.;  Ivanova, L.; Kobach Bølling, A.; Lagadic-Gossmann, D.; Refsnes, M.; Becher, R.; Eriksen, G. S.; Holme, J. A. Enniatin B-induced cell death and inflammatory responses in RAW 264.7 murine macrophages. Toxicol. Appl. Pharmacol. 2012, 261, 74-87.
    Ansteinson, V.; Solhaug, A.; Samuelsen, J. T.; Holme, J. A.; Dahl, J. E. DNA damage, cell-cycle arrest and apoptosis induced in BEAS-2B cells by 2-hydroxyethyl methacrylate (HEMA). Mutat. Res. 2011, 723, 158-164.

    Landvik, N. E.; Arlt, V. M.; Nagy, E.; Solhaug, A.; Tekpli, X.; Schmeiser, H. H.; Refsnes, M.; Phillips, D. H.; Lagadic-Gossmann, D.; Holme, J. A. 3-Nitrobenzanthrone and 3-aminobenzanthrone induce DNA damage and cell signalling in Hepa1c1c7 cells. Mutat. Res. 2010, 684 (1-2), 11-23.

    Rakkestad, K. E.; Skaar, I.; Ansteinsson, V. E.; Solhaug, A.; Holme, J. A.; Pestka, J. J.; Samuelsen, J. T.; Dahlman, H. J.; Hongslo, J. K.; Becher, R. DNA damage and DNA damage responses in THP-1 monocytes after exposure to spores of either Stachybotrys chartarum or Aspergillus versicolor or to T-2 toxin. Toxicol. Sci. 2010, 115 (1), 140-155.
    Asare, N.; Tekpli, X.; Rissel, M.; Solhaug, A.; Landvik, N.; Lecureur, V.; Podechard, N.; Brunborg, G.; Lag, M.; Lagadic-Gossmann, D.; Holme, J. A. Signalling pathways involved in 1-nitropyrene (1-NP)-induced and 3-nitrofluoranthene (3-NF)-induced cell death in Hepa1c1c7 cells. Mutagenesis 2009, 24 (6), 481-493.
    Olsen, P. A.; Solhaug, A.; Booth, J. A.; Gelazauskaite, M.; Krauss, S. Cellular responses to targeted genomic sequence modification using single-stranded oligonucleotides and zinc-finger nucleases. DNA Repair (Amst) 2009, 8 (3), 298-308.
    Holme, J. A.; Gorria, M.; Arlt, V. M.; Ovrebo, S.; Solhaug, A.; Tekpli, X.; Landvik, N. E.; Huc, L.; Fardel, O.; Lagadic-Gossmann, D. Different mechanisms involved in apoptosis following exposure to benzo[a]pyrene in F258 and Hepa1c1c7 cells. Chem. Biol. Interact. 2007, 167 (1), 41-55.
    Huc, L.; Tekpli, X.; Holme, J. A.; Rissel, M.; Solhaug, A.; Gardyn, C.; Le, M. G.; Gorria, M.; manche-Boitrel, M. T.; Lagadic-Gossmann, D. c-Jun NH2-terminal kinase-related Na+/H+ exchanger isoform 1 activation controls hexokinase II expression in benzo(a)pyrene-induced apoptosis. Cancer Res. 2007, 67 (4), 1696-1705.
    Landvik, N. E.; Gorria, M.; Arlt, V. M.; Asare, N.; Solhaug, A.; Lagadic-Gossmann, D.; Holme, J. A. Effects of nitrated-polycyclic aromatic hydrocarbons and diesel exhaust particle extracts on cell signalling related to apoptosis: possible implications for their mutagenic and carcinogenic effects. Toxicology 2007, 231 (2-3), 159-174.
    Huc, L.; Rissel, M.; Solhaug, A.; Tekpli, X.; Gorria, M.; Torriglia, A.; Holme, J. A.; manche-Boitrel, M. T.; Lagadic-Gossmann, D. Multiple apoptotic pathways induced by p53-dependent acidification in benzo[a]pyrene-exposed hepatic F258 cells. J. Cell Physiol 2006, 208 (3), 527-537.
    Solhaug, A.; Ovrebo, S.; Mollerup, S.; Lag, M.; Schwarze, P. E.; Nesnow, S.; Holme, J. A. Role of cell signaling in B[a]P-induced apoptosis: characterization of unspecific effects of cell signaling inhibitors and apoptotic effects of B[a]P metabolites. Chem. Biol. Interact. 2005, 151 (2), 101-119.
    Solhaug, A.; Refsnes, M.; Holme, J. A. Role of cell signalling involved in induction of apoptosis by benzo[a]pyrene and cyclopenta[c,d]pyrene in Hepa1c1c7 cells. J. Cell Biochem. 2004, 93 (6), 1143-1154.
    Solhaug, A.; Refsnes, M.; Lag, M.; Schwarze, P. E.; Husoy, T.; Holme, J. A. Polycyclic aromatic hydrocarbons induce both apoptotic and anti-apoptotic signals in Hepa1c1c7 cells. Carcinogenesis 2004, 25 (5), 809-819.
    Anthonsen, M. W.; Solhaug, A.; Johansen, B. Functional coupling between secretory and cytosolic phospholipase A2 modulates tumor necrosis factor-alpha- and interleukin-1beta-induced NF-kappa B activation. J. Biol. Chem. 2001, 276 (32), 30527-30536.
    Anthonsen, M. W.; Andersen, S.; Solhaug, A.; Johansen, B. Atypical lambda/iota PKC conveys 5-lipoxygenase/leukotriene B4-mediated cross-talk between phospholipase A2s regulating NF-kappa B activation in response to tumor necrosis factor-alpha and interleukin-1beta. J. Biol. Chem. 2001, 276 (38), 35344-35351.

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